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This positions the compound as a tool for investigating extracellular matrix remodeling signaling

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According to Unani scholars, it is caused by Ghadha-i-Ghalizkham (foods that are partially cooked and hard to digest), disturbance in Quwwat-i-Hadm , 64 stomach weakness, Fudlat (waste product), intake of spicy foods, rotten fruits, hard fibrous diets, alcoholism, indigestion, gastric secretions, prolonged stress, and strain

Wozniacka A, Sysa-Jedrzejowska A, Adamus J, Gebicki J

Less Common Joint pain or stiffness Numbness or tingling These typically resolve with continued use or dose adjustment