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Therefore, the prohibition of smoking may effectively control the occurrence of AAA and the occurrence of serious complications ( Smoking-Related Molecular Mechanisms At present, the pathogenesis of AAA is mainly attributed to inflammatory cell infiltration, the destruction of elastin and collagen in the media and adventitia, biological changes in smooth muscle cells and angiogenesis (180, 181)

Some studies suggest that priming peripheral blood mononuclear cells (PBMCs) with urate enhances the release of interleukin-1 (IL-1) in response to lipopolysaccharide (LPS), indicating a potential pro-inflammatory effect

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These results suggested that the addition of glucose rerouting the metabolism ( grd operon is strongly up-regulated (8- to 60-fold) in the sigL::erm mutant (Supplementary Table S7)