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Front Physiol 9(5):141 Muoz-Casares FC, Padillo FJ, Briceo J, Collado JA, Muoz-Castaeda JR, Ortega R, Cruz A, Tnez I, Montilla P, Pera C, Muntan J (2006) Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas

The use of P5091 or P22077, two USP7 inhibitors, display a strong senolytic activity in several models of senescence 31

Its levels are normally very low in most tissues but are rapidly up-regulated during the inflammatory process by proinflammatory substances (e.g., cytokines, endotoxins, and tumor promoters)

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