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Leptin levels can be measured, and researchers have proposed various theories about why people become resistant to the weight-loss hormone

Upston JM, Witting PK, Brown AJ, Stocker R, Keaney JF, Jr

Propionylcarnitine, a metabolite in equilibrium with propionyl-CoA which feeds into the TCA cycle through conversion to succinyl-CoA, was significantly reduced (log2FC 6.93, FDR = 0.0006) in IBM (Fig