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, dorsal thalamus, hippocampus, lateral geniculate body, hypothalamus, dorsal raphe nucleus, substantia nigra, medial anterior olfactory nucleus, lateral caudate, accumbens nucleus, superior olive)) (shown by the very precise alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method) (16, 20)

La extrapolacin de estas dosis al ser humano, utilizando los factores de conversin alomtricos estndar (factor de 6,2 para la rata), da dosis tericas del orden de 1,6 g/kg en humanos

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Conversely, increased levels of choline and myo-inositol in the prefrontal cortex suggest neuroinflammation and glial activation, consistent with the inflammatory processes observed in METH-induced neurotoxicity ( Behavioral assessments aligned closely with these imaging findings, offering a clinical perspective on the neurological damage caused by METH abuse

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