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The sequential probiotics used in this trial were: a combination of Enterococcus faecium UBEF-41, L

Inhibition of superoxide dismutase by 2methoxyoestradiol analogues and oestrogen derivatives: structureactivity relationships

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Because FOXO4-DRIs mechanism depends on disrupting the FOXO4p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population leaving FOXO4-low non-senescent cells largely unaffected