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KEGG pathway enrichment analysis of differentially expressed genes between clusters or samples was performed using limma and biomaRt

10.1371/journal.pone.0045825 PLoS ONE 108 XuQ.JiangY.YinY.LiQ.HeJ.JingY.et al (2013)

A typical course lasts between 5 to 8 months, though some treatments can extend to 12 months to ensure optimal results

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