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Our APAP model [10] is simple because it does not include the processing of GSH in the mitochondria that has been shown to be fundamental for liver cell death in the presence of APAP [36]

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Non-Classical Pathways Unlike full-length hGH, which exerts its lipolytic effects through the classical GH receptor and JAK-STAT signaling, AOD-9604 operates through alternative, receptor-independent pathways

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