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==== 00:00 Intro 03:12 Epigenetics and Neurodegenerative Disease 04:49 Why Alzheimers Is Not a Single Gene Disorder 09:18 Protein Aggregation and Brain Cleanup Failure 10:55 Microglia vs Neurons in Alzheimers 19:04 Blood Brain Barrier and Inflammatory Signaling 20:39 ApoE Genetics Explained 23:37 Human Microglia Transplanted Into Mouse Brain 30:02 Vitamin D Receptor and Protective Gene Programs 38:18 Environmental Toxins and Parkinsons 44:59 C1q Activation and Synapse Loss 49:33 Why Substantia Nigra Is Uniquely Vulnerable 51:39 Paraquat, Mitochondria and Converging Toxic Pathways 53:00 Epigenetic Memory of Toxic Exposure 54:09 Histones and Gene Regulation in Alzheimers 57:41 Oligodendrocytes as a Hidden Player 59:32 Why Single Target Drugs May Fail 01:02:10 Detecting Disease Through Blood and Machine Learning 01:04:41 Can Lifestyle Modify Epigenetics ==== Dr Sarah Marzi is a Senior Lecturer in Neuroscience at Kings College London and a Group Leader at the UK Dementia Research Institute

And so you really have to stay in a longer period of time