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Oxidative stress alters the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), which contributes to the generation of pain in inflammatory conditions [96]

However, other stressors such as a quick walk, a glass of wine, or a temperature change have also been known to trigger relapses in ME/CFS (63)

10.1002/fsn3.3237 Food Sci Nutr

Caffeine: The Metabolic Pathways Involved in Biotransformation and Oxidative Stress As a natural xanthine derivative, structurally similar to endogenous purine nitrogenous bases, caffeine is metabolized almost entirely and involves both microsomal (especially CYP1A2) and non-microsomal enzyme xanthine oxidase (XO)see Figure 2