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PLGA and other biodegradable carriers can readily be functionalized with GSH-cleavable linkers or redox-sensing moieties, providing clinically tractable routes to translate GSH-responsive designs into precision treatments [23]

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DOI: 10.1136/bmj.305.6855.693 Oldendorf WH (1971): Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

One more thing, a bacteria can enter from there and may cause infection