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Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)

Alterations in histone acetylation and DNA methylation affect the transcription of key autophagy genes such as ATG5 and LC3B

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Urolithin A is a metabolite derived from ellagitannins found in foods such as pomegranates, whereas spermidine is a naturally occurring polyamine found in various plant-based foods such as wheat germ and soyabeans

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