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Especially many academic groups are industriously contributing to the design and discovery of novel antibacterial agents using both natural sources [223,224,225,226,227,228,229] and synthetic approaches [230,231,232,233,234], as well as innovating novel therapeutic strategies such as employing adjuvants [235,236,237], photosensitizers [238] and multifunctional materials [239, 240] in addition to those discussed in this review

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Sepiapterin is a stable precursor in the salvage pathway of BH 4 biosynthesis, which converts sepiapterin to BH 4 via the activities of sepiapterin reductase and DHFR (Figure 8)

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