Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction
The most reliable diagnostic approach combines several complementary tests rather than relying on a single marker
Nedachi T, Bonod C, Rorteau J, Chinoune W, Ishiuchi Y, Hughes S, et al
Glutathione is produced in the liver and occurs naturally in foods high in sulfur
Characteristics of First-in-Human Clinical Trials Important aspects of FIH trials include the selection of a starting dose, a dose acceleration schedule, the study duration, and the administration route of the study drug