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Activity observed in animal models or small early studies does not automatically translate into predictable, beneficial effects in human patients, and none of this constitutes a basis for DSIP dosage recommendations

Accessed 12 Feb 2026

In certain regions of the world, marginal or subclinical vitamin B 12 deficiency may be fairly common in other age groups as well, including children, premenopausal women, and pregnant women, primarily due to low intake of animal-source foods (reviewed in 5)

Vitamin C supplements should meet the RDA and stay well below the established UL 400 for young children, 1,200 mg for kids aged 913, 1,800 mg for teens, and 2,000 mg for adults