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ES2 is a senolytic peptide that targets FOXO4 CR3 but exhibits relatively poorer selectivity for senescent cells compared to FOXO4-DRI 25 (Table S1)

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Moreover, several studies have revealed that LCINS are also genomically and molecularly distinct from smoking-related lung cancers, highly enriched for targetable oncogenic alterations (such as EGFR mutations or ALK rearrangements as well as less common alterations), and thus often require different diagnostic and therapeutic strategies

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