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Specifically, we used a random intercept in the mixed-effects model to account for the within-study correlation and used a study-specific random slope with respect to the signal to capture between-study heterogeneity

Tar coats the inside of the lungs, forming a sticky layer that can lead to cancer, emphysema, and other serious conditions

This type of preemption can be problematic for local tobacco advocates who recognize that state and federal policy is often too broad to address the specific and unique needs of their community

However, it dropped in 2015 to $17.72 billion

Supplementary information Additional file 1: Table S1