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Ethics declarations Conflict of interest The authors declare that there exists no competing financial interest or personal relationships that could have appeared to influence the work reported in this paper

This antagonistic effect of polyphenols has been previously observed by Lui et al

Outcomes differ by dose, route (including intravenous glutathione), cofactors like ascorbic acid, baseline skin pigmentation, and dark spots

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Clinical Trial Findings Oral Bioavailability Challenge: Randomized controlled trials (RCTs) on standard oral GSH supplementation show mixed and controversial results