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Funding This work was supported by the National Natural Science Foundation of China (82270646), the Jiangsu Province Concept Verification Center-Nanjing Drum Tower Hospital Special Fund Project (2024-GNYZ-ZD-03), the Clinical Trials from Nanjing Drum Tower Hospital (2022-LCYJ-PY-35), Project of Chinese Hospital Reform and Development Institute, Nanjing University, and Aid project of Nanjing Drum Tower Hospital Health, Education & Research Foundation (NDYG2022057)