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After endocytic internalization, the fate of CPP/cargo complexes primarily relies on their ability for endosomal escape before their transport into the endosome, a site for enzymatic degradation ( Use of CPPs enables the noninvasive delivery of macromolecular drugs, such as nucleic acids, proteins, imaging agents, viruses, and CPP/cargo complexes through various mechanisms of transduction pathways without perturbing the membrane integrity (Xie et al., 2020

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Hydration and avoiding strenuous activity for a day can also help

Treatments for keloids remain unsatisfactory because the key pathophysiological mechanism is unknown 1

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