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Although melatonin-dependent mPTP modulation has been widely described with concordant results, related molecular mechanisms have only been proposed

10.1104/pp.110.153957 12 ChenJ

Traditional treatment strategies focus mostly on a single driving mechanism of aging, such as clearing senescent cells through senolytics, extending telomeres with telomerase activators, or supplementing NAD + precursors to improve mitochondrial function