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This process increases mitochondrial membrane permeability, leading to the release of the cytochrome C into the cytosol, thereby accelerating the initiation of apoptosis initiation and ultimately decreasing the mitochondrial membrane potential (MMP) ( Moreover, the MRC is a major site for ROS production, and in the presence of hyperglycaemia, damaged mitochondria produce excessive electron leakage in MRC complex I and at the interface between MRC complex III and coenzyme Q ( 2.3 Mitochondrial dynamics disorders and DN The process of changing mitochondrial morphology, location and quantity within eukaryotic cells is tremed as mitochondrial dynamics, which maintains a dynamic equilibrium through constant fusion and fission ( It was discovered that highly fragmented and discrete mitochondria were present in high glucose-induced human podocytes, which cover the outer side of glomerular capillaries and are essential for the glomerular filtration barrier