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Further exploration of the mechanism, both the inhibitors 5a and 5b were found to be reversible and competitive

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doi: 10.3389/fnut.2022.1011002 Received 03 August 2022 Accepted 29 September 2022 Published 31 October 2022 Volume 9 - 2022 Edited by Ming Yang, Sichuan University, China Reviewed by Mahesh Kumar Samota, Central Institute of Post-Harvest Engineering and Technology (ICAR), India

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Initial medical management guidelines In the initial medical management of acute hyperammonaemia, the patient should be immediately stabilized (circulation, airway and breathing), vital signs should be addressed, blood glucose levels monitored, intravenous access should be established, airways should be maintained by intubation and ventilation if necessary, and adequate rehydration should be started, typically using a dextrose-containing fluid at a high infusion rate 23