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Grosse: nothing to disclose, Johanna Ernst: nothing to disclose Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, OMICS AND BIOMARKERS P1056 - ESOC25-766 REGULATORY AUTOANTIBODIES AND CLINICAL OUTCOME AFTER ISCHEMIC STROKE (PROSCIS-B) Anna-Sophia Miesenberger 1,2 , Pia Sophie Sperber 1,2,3 , Friederike Antonia Arlt 2,4 , Pimrapat Gebert 5 , Harald Heidecke 6 , Guido Moll 7,8,9 , Rusan Ali Catar 7 , Leif Koschtzke 1,2 , Christoph Harms 1,2 , Anna Kufner 1,2 , Thomas Liman 1,2,4 , Matthias Endres 1,2,4 1 Center for Stroke Research Berlin (CSB), Berlin, Charit - Universittsmedizin Berlin, corporate member of Freie Universitt Berlin and Humboldt-Universitt zu Berlin, Berlin, Germany, 2 Department of Neurology and Experimental Neurology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt Berlin, Berlin, Germany, 3 Experimental and Clinical Research Center, a Cooperation Between Max Delbrck Center for Molecular Medicine in the Helmholtz Association, Charit Universittsmedizin Berlin, Geschftsfhrung, Charitplatz 1, 10117 Berlin, Germany, Berlin, Germany, 4 German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany, 5 Institute of Biometry and Clinical Epidemiology, Charit-Universittsmedizin Berlin, Corporate member of Freie Universitt and Humboldt-Universitt zu Berlin, Berlin, Germany, 6 CellTrend GmBH, Luckenwalde, Germany, 7 Department of Nephrology and Internal Intensive Care Medicine, Charit-Universittsmedizin Berlin, Corporate member of Freie Universitt and Humboldt-Universitt zu Berlin, Berlin, Germany, 8 BIH Center for Regenerative Therapies (BCRT), Berlin, Germany, 9 Julius Wolff Institute for Musculoskeletal Research (JWI), Berlin, Germany Background and Aims: The relevance of GPCR-directed regulatory autoantibodies (RABs) in stroke is unclear

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