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doi:10.1136/tobaccocontrol-2013-051469

Virginia or flue-cured tobacco is by far the most widely cultivated tobacco type globally, prized for its high sugar content (typically 15-25%), low alkaloid levels, and characteristic mild, slightly sweet flavor profile that forms the backbone of most globally consumed cigarette blends

Maybe this is an outsiders perspective, but based on what I see published (which requires it to have received IRB approval) it seems like these kinds of studies are so standard that they are rubber-stamped by IRBs