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A major mechanism underlying desensitization is phosphorylation of the GPCR (Stadel et al ., 1983

10.1194/jlr.M034249 42 LebrechtD.Vargas-InfanteY

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The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG