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The half-life of nicotine is around 2 hours, while the half-life of cotinine is 7 to 40 hours

Second, if multiple risk estimates with different adjustment levels were reported in a given study, we included only the fully adjusted risk estimate and modeled the adjustment level according to the number of covariates adjusted for (rather than which covariates were adjusted for) and whether a standard adjustment for age and sex had been applied

& Jeffery, P

The methodological approaches primarily consist of quantitative online cross-sectional surveys and experiments

Smoking is proven to be extremely bad for your health