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The reported adverse reactions following parenteral administration of vitamin B12 include: Generalized: Anaphylaxis and death Cardiovascular: Pulmonary edema and congestive cardiac/heart failure during early treatment

Lateral epicondylar tendinopathy (tennis elbow) that is refractory to the usual interventions of physical therapy/home-directed exercise, ice therapy, corticosteroid injections, and rest is a relatively common but very difficult clinical situation

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The prevailing theory on why Vitamin B12 may be effective in many neuromuscular and other conditions is that the METHYL (methylcobalamin) group acts to aid in detoxification and to improve cellular energy