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Although homocysteine thiolactone has not been unequivocally identified in vivo , it might be a major by-product of deregulated homocysteine metabolism

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128 In addition, histone Kla, especially H3K18la, facilitates proteasome 26S subunit, non-ATPase 14 (PSMD14) upregulation, leading to neuronal PANoptosis and improved TBI prognosis by deubiquitinating PKM2 to activate PINK1-mediated mitophagy

It is defined as weight in kilograms (kg) divided by height in meters squared (m 2 ) where a BMI of 2529.9 kg/m 2 is classified as overweight and a BMI 30 kg/m 2 is classified as obese

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