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One could conveniently conclude, oh, well, all depression is a B vitamin deficiency, but of course that's not true

My breathing has improved significantly, and I no longer feel as restricted in my daily activities

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Oral B12 supplements rely on the digestive system for absorption, which can be significantly impaired by gut conditions, age-related changes, or the absence of intrinsic factor (a protein required for B12 absorption)

Sustained elevation of hepatic enzymes occurs in roughly 15% of patients at standard doses of 0.5 to 1 mg/kg/day, which is why the iPLEDGE program mandates liver function testing at baseline and at each monthly visit [2]