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In brief, in cases of low mitochondrial membrane potential, the JC-10 monomer is unable to accumulate in the mitochondrial matrix and, as a consequence, green fluorescence is produced

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Glutathione can "recharge" it, and vice versa

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doi: 10.1002/mnfr.202300602 288 GubatanJKulkarniCVTalamantesSMTembyMFardeenTSinhaSR