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In vitro cell models of the BBB offer many advantages such as the ability to test the effects of molecules on specific cell types in a high throughput manner, and to investigate several cellular mechanisms simultaneously and repetitively [120]

That said, absence of known interactions doesnt guarantee that none exist

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Nonmotor symptoms, including autonomic dysfunction, cognitive decline, and psychological disturbances, further highlight the systemic impact of PD and its pathophysiology [6,7]