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In the FSP1/CoQ10/NAD(P)H axis, FSP1 reduces CoQ10 to generate the antioxidant CoQH2 independently of GPX4, inhibits lipid peroxidation [81], and cooperates with vitamin K metabolism to protect cells [82]

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78 A statistical analysis that included nine randomized controlled trials, involving a total of 591 women with PCOS, also reported finding omega-3 fatty acid supplementation improved insulin sensitivity, lowered total cholesterol and triglyceride levels, and raised levels of adiponectin (a signaling peptide primarily produced by fat tissue that improves insulin sensitivity and has anti-inflammatory properties)

Similarly, dysregulation of System Xc- limits cysteine availability, impairing glutathione synthesis and escalating oxidative stress