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The high and selective expression of the 5-HT 3 serotonin receptor on sensory neurons of the vagus nerve allow a fast central detection of peripheral serotonin changes (205)

KEAP1 promotes the ubiquitination and degradation of NRF2 under normal physiological conditions

They act on multiple targets across interconnected signaling pathways, generally show favorable safety profiles with limited off-target toxicity, and may reduce the risk of resistance development, which remains a major challenge in chronic inflammatory disorders such as endometriosis (EMs)

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024 STAGE 2 Lv