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Essentially, when NLRP3 activates, it causes caspase-1 activation, which in turn activates interleukin-1 (IL-1) and interleukin-18 (IL-18)

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Cis association of galectin-9 with Tim-3 differentially regulates IL-12/IL-23 expressions in monocytes via TLR signaling

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Consisting of dimeric transcription factors such as Jun and Fos, AP-1 binds to DNA motifs, such as TPA-responsive element (TRE) and cAMP-responsive element (CRE), initiating transcription of genes critical for cell survival and stress adaptation 73,74