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Hence, this impaired HSP production (302) combined with oxidative and nitrosative stress, and low-grade inflammation could explain the exercise intolerance and muscle dysfunction seen in ME/CFS patients (303, 304)

While this regulatory oversight is designed to protect public health, it also means that patients and providers must navigate a more complex landscape to access these treatments

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S., Pistilli, E., Guerron, A

It can show up in infections, IBD, heavy alcohol use, chronic stress, and long-term NSAID use