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In the context of protein oxidation, the relationship between AGEs and the generation of AOPPs is noteworthy (Figure 2) ( AGEs are produced in a slow and controlled process, accumulating in the body, including the skin ( 3.2.3 Protein carbonylation In addition to AOPPs and AGEs, protein carbonylation (PC) serves as another marker of protein oxidation in patients with AD

An earlier study demonstrated that spermidine was able to alleviate the severity of murine EAE (114)

In some embodiments, the otic formulation or composition comprises about 0.9% by weight of the viscosity modulating agent(s)

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