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Yes, IQOS Heets contain nicotine derived from tobacco, with levels varying by flavor

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Citation on PubMed Brady AF, Demirdas S, Fournel-Gigleux S, Ghali N, Giunta C, Kapferer-Seebacher I, Kosho T, Mendoza-Londono R, Pope MF, Rohrbach M, Van Damme T, Vandersteen A, van Mourik C, Voermans N, Zschocke J, Malfait F

Fungicides and biocontrol bacteria are used in most cases nowadays, but the long-term use of fungicides leads to a series of problems, such as pesticide residues and environmental pollution, and there are limitations to biocontrol bacteria which restrict the sustainability of flue-cured tobacco industry 5,9,10