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There is no robust body of randomized controlled trial data demonstrating that lipotropic injections cause clinically significant fat loss beyond what the accompanying calorie restriction, activity changes, and clinical monitoring would have produced anyway

New tools and approaches, e.g., 34 S labeling, exploitation of natural variation, and mathematical modeling will be necessary to obtain the comprehensive list of S-metabolite transporters and to understand the role they play in controlling sulfur metabolism and homeostasis in plants

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Severe cases might justify exploring periocular or intravitreal routes if pharmaceutical formulations developed though not currently available for research peptides