As always this stuff reminds me of Glenn Grohes 1942 poster: Hes Watching You. The internets favorite dictionary just dropped a new word game, Tagline and, surprisingly, theres not a definition in sight
The decrease in SOD2 in OA chondrocytes is related to the increase in promoter methylation (Scott et al., 2010)
Leiter, L
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Chronic oxidative stress is linked to a wide range of diseases, including: Cardiovascular disease : ROS damage endothelial cells lining blood vessels, promoting atherosclerosis and hypertension.[9] Neurodegenerative disorders : Oxidative damage to neurons is a key driver in conditions like Alzheimers, Parkinsons and ALS.[10] Diabetes and insulin resistance : Oxidative stress impairs insulin signaling and worsens glycemic control.[10] Cancer : DNA mutations caused by free radical damage may initiate or accelerate tumor development.[11] Autoimmune conditions : Oxidative stress can trigger inflammatory pathways, contributing to immune dysregulation.[9] Even outside of these conditions, oxidative stress contributes to fatigue, slower recovery, immune suppression and premature aging at the cellular level
