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If the issue lies with absorption, B12 shots or IV infusions are an effective alternative to oral supplements because they are administered via injection or intravenously, meaning they do not need to be absorbed through the digestive process

Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

[DOI] [PubMed] [Google Scholar] 5.Allen LH, Rosado JL, Casterline JE, Lopez P, Muoz E, Garcia OP, Martinez H

Muscle wasting research is a particularly promising area