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At a further level of complexity, many nanoplatforms are also engineered to interact with defined immune cell populations or signaling pathways, with the aim of partially relieving immunosuppressive features of the tumor microenvironment and creating conditions more permissive for systemic immunotherapy or rational combination regimens [9, 29, 35]

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Liposomes, with their phospholipid bilayers mimicking cell membranes, provide high encapsulation efficiency for both hydrophilic and hydrophobic drugs and have pioneered clinical translation [139]

Scientists use BPC-157 peptide to investigate fundamental cellular and tissue-level signaling mechanisms

Oncotarget 8 , 3765737672 (2017)