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For example, the mesolimbic dopaminergic pathway composed of dopaminergic (DA) neurons in the ventral tegmental area (VTA) and their projections to the nucleus accumbent (NAc) is crucial for the recognition of emotionally salient stimuli such as reward and aversion

How its thought to work HPA/stress modulation dampens cortisol drive calming, not sedating

Oxidative stress (OxS)/cellular damage Oxidative stress (OxS) is a nonspecific pathophysiological condition that reflects a redox imbalance between increased production of ROS (free radicals) and the inability of antioxidant defenses to neutralize the reactive intermediates or to repair the ensuing damage 179,180

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Therefore, it is necessary to further conduct high-quality research to explore the efficacy, safe dosage, and adverse effects of TCM on the human body