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The molecule size makes penetrating the subcutaneous layers and then the bloodstream difficult

"Purification and characterization of eight glutathione S-transferase isoenzymes of hamster

30 showed that hair-follicle activation in Wnt -active dermal cells promotes their fate conversion into dermal papilla (DP), the regenerative dermal niche for hair-follicle formation

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doi: 10.1007/s00294-003-0415-2 32 DenegaI.d'EnfertC.Bachellier-BassiS