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Moreover, in breast cancer, IGF-1 mainly upregulates cysteine-rich 61 (Cyr61) by activating the PI3K/AKT pathway and an increase in Cyr61 promotes the growth and invasion of breast cancer cells (27)
proangiogenic factors (i.e., upregulated after wound healing even in the absence of new vessels) (for a review, see, i.e., [126,127,128])
Theres no specific stopping protocol or rebound effect to worry about with topical use