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doi:10.1016/j.ijporl.2012.11.037

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These data revived interest in the extracellular LLF glutathione pool and suggested that GGT activity in LLF is a novel target to treat asthma ( Human pharmacotherapy with acivicin, however, is limited by neurotoxicity and cytotoxicity caused by an extended inhibitory activity against a number of other glutamine-dependent biosynthetic enzymes ( in vivo , physical stability in vitro and extended inhibitory activity against mammalian as well as bacterial GGT ( MATERIALS AND METHODS INHIBITORY ACTIVITY OF GGsTop IN VIVO A crystalline form of GGsTop was synthesized according to the previous report ( C and aliquoted for experiments

Although the predominance of available literature from in vivo ischemic studies has focused on the involvement of synaptic vesicle zinc, it is likely that intracellular zinc accumulation during ischemia is achieved through a possible synergism of zinc release from both synaptic and intracellular stores of zinc, as most recently demonstrated during global ischemia (38) and reported in other experimental paradigms (4551)