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Behav Brain Res 378:112296 Xia D, Yuan J, Jiang X et al (2021) SIRT1 promotes M2 microglia polarization via reducing ROS-Mediated NLRP3 Inflammasome signaling after subarachnoid hemorrhage

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Stress can alter the production of peptide hormones and cytokines, contributing to inflammation and immune dysfunction

Rather than focusing on constant stimulation, modern approaches emphasize conditions that support natural pulsessuch as sleep quality, nutrient availability, and post-training recovery environments

Different pathways have been recently identified to play a key role in the escape of the immune system in senescence, highlighting the potential development of significant senolytic therapies in the future (Fig