It is known that As(III) species are much more toxic than those of As(V) and that biological methylation can enhance or reduce the toxicity of the different forms
Patients in BE OPTIMAL were randomized 3:2:1 to receive subcutaneous (SC) bimekizumab 160 mg every 4 weeks (Q4W), placebo, or the reference biologic (SC adalimumab [ADA] 40 mg Q2W)
In fact, replenishing glutathione levels may improve cell function in diseases like ulcerative colitis and prevent further cell damage by protecting against the harmful effects of oxidative stress
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Gomez D, Blumenschein G, Lee J, Hernandez M, Camidge R, Doebele R, Gaspar L, Karam J, Kavanagh B, Louie A, Palma D, William W, Zhang J, Swisher S , Heymach J