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Moreover, the safety profiles of both medications have been extensively studied, revealing that while they may cause gastrointestinal side effects, these are often mild and transient
Few human or murine studies exist regarding the influence of aging on susceptibility to drug induced liver injury 35 , which is often complicated by confounding factors including polypharmacy and genetics, among others
Mechanistically, this tracks with the central role of the thymus and circadian signals in T-cell competence as we age
Diverse first-line therapeutic approaches seem to differently affect lipid metabolism since a significant reduction in triglycerides has been found in patients undergone pituitary surgery whereas a significant decrease in total cholesterol has been shown after DAs therapy (62)
