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Hydroxyurea-induced hyperpigmentation

As mentioned earlier, imbalance in the AMPK/mTOR energy-sensing pathway under diabetic conditions is a key mechanism driving metabolic stress and fibrotic transformation in alveolar epithelial cells

9 Notably, insulin signalingparticularly through the PI3K-Akt pathwayplays a dual role: it not only regulates glucose metabolism but also promotes SC differentiation and remyelination, thereby mitigating DPN progression

[DOI] [PMC free article] [PubMed] [Google Scholar] 241.Dysken M.W., Sano M., Asthana S., Vertrees J.E., Pallaki M., Llorente M., Love S., Schellenberg G.D., McCarten J.R., Malphurs J., et al